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中华乳腺病杂志(电子版) ›› 2015, Vol. 09 ›› Issue (05) : 312 -315. doi: 10.3877/cma. j. issn.1674-0807.2015.05.006

论著

乳腺癌组织中凋亡抑制蛋白Apollon 的表达及其临床意义
陈建发1,(), 岳志强1, 傅明1, 莫友1, 周淑蓉1   
  1. 1.524009 广东湛江,解放军第四二二中心医院普通外科
  • 收稿日期:2015-05-06 出版日期:2015-10-01
  • 通信作者: 陈建发
  • 基金资助:
    湛江市财政资金科技专项(2012C0302)

Expression of apoptosis protein inhibitor Apollon in breast cancer tissue and its clinical significance

Jianfa Chen1,(), Zhiqiang Yue1, Ming Fu1, You Mo1, Shurong Zhou1   

  1. 1.Department of General Surgery, No.422 Hospital of PLA, Zhanjiang 524009,China
  • Received:2015-05-06 Published:2015-10-01
  • Corresponding author: Jianfa Chen
引用本文:

陈建发, 岳志强, 傅明, 莫友, 周淑蓉. 乳腺癌组织中凋亡抑制蛋白Apollon 的表达及其临床意义[J/OL]. 中华乳腺病杂志(电子版), 2015, 09(05): 312-315.

Jianfa Chen, Zhiqiang Yue, Ming Fu, You Mo, Shurong Zhou. Expression of apoptosis protein inhibitor Apollon in breast cancer tissue and its clinical significance[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2015, 09(05): 312-315.

目的

研究乳腺癌组织中凋亡抑制蛋白Apollon 免疫组化表达及临床意义。

方法

回顾性收集解放军第四二二医院2010 年1 月至2014 年12 月手术切除的女性乳腺癌组织标本66 例,采用免疫组织化学法检测66 例乳腺癌组织中Apollon、HER-2 及survivin 的表达。 采用Kendall 等级相关检验分析Apollon 表达与HER-2 表达、survivin 表达、肿瘤大小及淋巴结状态之间的相关性。

结果

在乳腺癌组织中Apollon、HER-2 及survivin 的阳性表达率分别为59.1% (39/66)、31.8% (21/66)及39.4% (26/66)。Apollon 表达与HER-2 表达(tau-b=0.370,P=0.003)、survivin 表达(tau-b=0.292,P=0.018)、肿瘤大小(tau-b=0.322,P=0.009)及淋巴结状态(tau-b=0.424,P=0.001)显著相关。

结论

Apollon 表达与HER-2 表达、Survivin 表达、肿瘤大小及淋巴结状态有关,其可能是一个与乳腺癌发展相关的潜在分子标志物。

Objective

To investigate the immunohistochemical expression of apoptosis protein inhibitor Apollon in breast cancer tissue and its clinical significance.

Methods

We retrospectively analyzed the female breast cancer tissue specimens from 66 cases treated in No.422 Hospital of PLA from January 2010 and December 2014. The expressions of Apollon, HER-2 and survivin were assessed immunohistochemically. The correlation of Apollon expression with HER-2 expression, survivin expression, tumor size and lymph node status was analyzed using Kendall rank correlation test.

Results

The positive rates of Apollon, HER-2 and survivin in breast cancer tissue were 59.1% (39/66),31.8% (21/66) and 39.4%(26/66), respectively. Apollon expression was significantly associated with HER-2 expression (tau-b=0.370, P=0.003), survivin expression(tau-b=0.292, P=0.018), tumor size (tau-b=0.322, P=0.009) and lymph node status (tau-b=0.424, P=0.001).

Conclusions

Apollon expression is associated with HER-2 expression, survivin expression, tumor size and lymph node status.Apollon may be a potential molecular marker in the development of breast cancer.

图1 Apollon、HER-2 及survivin 在乳腺癌组织中阳性表达(SP 法×200) 注:a、b、c 图分别所示Apollon、HER-2 及survivin 在乳腺癌组织中阳性表达
表1 66 例乳腺癌组织中Apollon 表达与HER-2、survivin、肿瘤大小及淋巴结状态的相关性
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